(Overall Record: 21-11; Atlantic 10 Record: 9-5)
All Times Eastern & Subject to Change
*Atlantic 10 Conference Games
| Date | Time | Opponent | Location | Results | Recap | Stats | Video | Audio | |
| Nov. 02, 2010 | Tuesday | 7:00 PM | Gannon - (ex) | UD Arena | W 101-60 | Recap | Stats | Video | Audio |
| Nov. 12, 2010 | Friday | 7:00 PM | Penn State | UD Arena | L 107-112 (2OT) | Recap | Stats | Video | Audio |
| Nov. 15, 2010 | Monday | 7:00 PM | Michigan State | East Lansing, MI | L 74-62 | Recap | Stats | Audio | |
| Nov. 20, 2010 | Saturday | 4:30 PM | South Dakota | Minneapolis, MN - Minnesota Subway Classic | W 78-56 | Recap | Stats | Audio | |
| Nov. 21, 2010 | Sunday | 4:30 PM | Minnesota | Minneapolis, MN - Minnesota Subway Classic | W 97-81 | Recap | Stats | Audio | |
| Nov. 27, 2010 | Saturday | 2:00 PM | UIC | UD Arena | L 66-65 | Recap | Stats | Video | Audio |
| Nov. 29, 2010 | Monday | 7:00 PM | Wright State | Fairborn, Ohio | W 91-61 | Recap | Stats | Video | Audio |
| Dec. 02, 2010 | Thursday | 7:00 PM | Cincinnati | UD Arena | W 70-59 | Recap | Stats | Video | Audio |
| Dec. 05, 2010 | Sunday | 2:00 PM | Toledo | UD Arena | W 102-69 | Recap | Stats | Video | Audio |
| Dec. 11, 2010 | Saturday | 5:00 PM | Louisville | Louisville, KY | L 69-55 | Recap | Stats | Video | Audio |
| Dec. 18, 2010 | Saturday | 10:00 PM | San Diego State | Los Angeles, CA - USC Women of Troy Tournament | L 74-62 | Recap | Stats | Video | Audio |
| Dec. 19, 2010 | Sunday | 6:00 PM | Colorado | Los Angeles, CA - USC Women of Troy Tournament | W 70-50 | Recap | Stats | Audio | |
| Dec. 22, 2010 | Wednesday | 5:00 PM | CSU-Bakersfield | Bakersfield, CA | W 98-78 | Recap | Stats | Audio | |
| Dec. 30, 2010 | Thursday | 7:00 PM | Harvard | UD Arena | W 101-80 | Recap | Stats | Video | Audio |
| Jan. 03, 2011 | Monday | 7:00 PM | Boston College | Chestnut Hill, MA | W 89-77 | Recap | Stats | Video | Audio |
| Jan. 09, 2011 | Sunday | 3:00 PM | Xavier * - (TV: ESPN2) | Cincinnati, OH | L 63-59 | Recap | Stats | Video | Audio |
| Jan. 12, 2011 | Wednesday | 8:00 PM | Saint Louis * | St. Louis, MO | W 84-62 | Recap | Stats | Video | Audio |
| Jan. 15, 2011 | Saturday | 2:00 PM | Duquesne * - (TV: CBS Regional) | UD Arena | L 61-57 | Recap | Stats | Audio | |
| Jan. 19, 2011 | Wednesday | 7:00 PM | George Washington * | UD Arena | W 80-64 | Recap | Stats | Video | Audio |
| Jan. 22, 2011 | Saturday | 7:00 PM | Richmond * | Richmond, Va. | W 66-55 | Recap | Stats | Video | Audio |
| Jan. 26, 2011 | Wednesday | 7:00 PM | La Salle * | UD Arena | W 85-51 | Recap | Stats | Video | Audio |
| Jan. 29, 2011 | Saturday | 2:00 PM | Saint Joseph's * | UD Arena | W 79-68 | Recap | Stats | Video | Audio |
| Feb. 02, 2011 | Wednesday | 7:00 PM | St. Bonaventure * | Olean, NY | W 87-80 (OT) | Recap | Stats | Video | Audio |
| Feb. 05, 2011 | Saturday | 2:00 PM | Xavier * | UD Arena | L 66-70 (OT) | Recap | Stats | Video | Audio |
| Feb. 09, 2011 | Wednesday | 11:00 AM | Massachusetts * | UD Arena | W 66-58 | Recap | Stats | Video | Audio |
| Feb. 12, 2011 | Saturday | 7:00 PM | Charlotte * | Charlotte, NC | L 73-52 | Recap | Stats | Video | Audio |
| Feb. 19, 2011 | Saturday | 5:00 PM | Temple * - (TV: CBS Regional) | Philadelphia, PA | L 76-52 | Recap | Stats | Audio | |
| Feb. 23, 2011 | Wednesday | 7:00 PM | Rhode Island * | Kingston, RI | W 63-43 | Recap | Stats | Audio | |
| Feb. 26, 2011 | Saturday | 2:00 PM | Fordham * | UD Arena | W 69-51 | Recap | Stats | Video | Audio |
| Mar. 04, 2011 | Friday | 7:30 PM | George Washington | Lowell, MA - A-10 First Round | W 61-58 | Recap | Stats | Audio | |
| Mar. 05, 2011 | Saturday | 7:30 PM | Duquesne | Lowell, MA - A-10 Quarterfinals | W 74-66 | Recap | Stats | ||
| Mar. 06, 2011 | Sunday | 2:30 PM | Temple - (TV: CBS College Sports) | Lowell, MA - A-10 Semifinal | W 75-67 | Recap | Stats | Audio | |
| Mar. 07, 2011 | Monday | 5:00 PM | Xavier - (TV: ESPN2) | Lowell, MA - A-10 Championship | L 67-60 | Recap | Stats | ||
| Mar. 19, 2011 | Saturday | 11:10 AM | Penn State - (TV: ESPN2) | University Park, PA - NCAA First Round | L 75-66 | Recap | Stats | Video | Audio |
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